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Mefloquine was launched there in 1983, https://www.fjallravenbackpack.com first on the Thai side and within the type of mefloquine in combination with sulfadoxine-pyrimethamine. These therapy failures almost certainly consequence from mefloquine resistance moderately than artemisinin resistance because elevated pfmdr1 copy number has been linked most carefully with mefloquine resistance in vivo (10,11). Monitoring of in vitro antimalaria drug susceptibility by the Pasteur Institute of Cambodia since 2001 additionally suggests progressive lack of mefloquine sensitivity in western Cambodia (2).